Modes of paramyxovirus fusion: a Henipavirus perspective
نویسندگان
چکیده
منابع مشابه
Structure of the primed paramyxovirus fusion protein.
V iruses with lipid envelopes must fuse their membranes with those of host cells to transfer their genomes and initiate infection. Depending on the virus, the membrane fusion process can occur at the plasma membrane, or at intracellular membranes following the internalization of virus particles. Not surprisingly, the viral proteins responsible for membrane fusion are highly diverse, as are the ...
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The Paramyxoviridae genus Henipavirus is presently represented by the type species Hendra and Nipah viruses which are both recently emerged zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These enveloped viruses bind and enter host target cells through the coordinated activities of their...
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The paramyxovirus family contains many common human pathogenic viruses, including measles, mumps, the parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the zoonotic henipaviruses, Hendra and Nipah. While the expression of a type 1 fusion protein and a type 2 attachment protein is common to all paramyxoviruses, there is considerable variation in viral attachment, the...
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The first step of viral infection requires the binding of the viral attachment protein to cell surface receptors. Following binding, viruses penetrate the cellular membrane to deliver their genome into the host cell. For enveloped viruses , which have a lipid bilayer that surrounds their nucleocapsids , entry into the host cell requires the fusion of viral and cellular membranes. This process i...
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Fusion of the lipid envelope of paramyxoviruses with the host cell plasma membrane during virus entry is mediated by the F protein, a trimeric extracellular transmembrane-anchored glycoprotein. During F-mediated fusion, its fusion peptide inserts into the host cell membrane, followed by large-scale refolding from a largely globular pre-fusion conformation to a golf tee-shaped postfusion conform...
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ژورنال
عنوان ژورنال: Trends in Microbiology
سال: 2011
ISSN: 0966-842X
DOI: 10.1016/j.tim.2011.03.005